Imminent cardiac arrest in caffeine toxicity should prompt intra-lipid therapy to scavenge the free serum caffeine. Caffeine exhibits ideal characteristics to be dialyzed, including low protein binding (36%), low molecular size (194), and a small volume of distribution (0.6 to 0.8 L/kg). Hemodialysis has been effective in severe, life-threatening caffeine ingestions. Īctivated charcoal can bind caffeine if the ingestion is recent, and repeated doses can help diminish serum levels via the enterohepatic circulation. Vasopressors, such as vasopressin or phenylephrine, can be used to maintain blood pressure (goal mean arterial pressure greater than 65 mm Hg) without worsening tachycardia. At last,Caffeine(58-08-2) safety, risk, hazard and MSDS, CAS,cas number,Use. You can also browse global suppliers,vendor,prices,Price,manufacturers of Caffeine(58-08-2). Procainamide, lidocaine, or bicarbonate have also been utilized for the treatment of tachydysrhythmias. Visit ChemicalBook To find more Caffeine(58-08-2) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. Beta-blockade with esmolol is useful for tachycardia. Hydration may be oral in minor cases, yet severe cases benefit from intravenous (IV) hydration. The primary treatment for minor caffeine ingestion is supportive. įatal caffeine overdose is relatively uncommon, and treatment data is limited to case reports. Cardiac monitoring allows evaluation of heart rate and early recognition of dysrhythmias such as ventricular ectopy or fibrillation. An electrocardiogram may demonstrate tachycardia, ST-segment depressions, or T-wave inversions. It is also important to obtain serum myoglobin and creatine kinase levels to monitor for rhabdomyolysis. Caffeine toxicity can result in hypokalemia, hypocalcemia, hyponatremia, and hyperglycemia. Ī venous blood gas may demonstrate anion gap metabolic acidosis, which can be severe. Lethal blood levels are typically above 80 to 100 mg/L, although one case occurred at 15 mg/L. Although not available in all hospitals, serum caffeine levels are generally obtained with an immunoassay. Serum caffeine levels can guide prognosis and therapy. Routine serum laboratory evaluations can be useful in drug overdose cases, especially in the setting of unstable vital signs, seizures, or altered sensorium.
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